Azumanga Daioh

This four-panel comedy chronicles the everyday lives of six very quirky high school girls. Meet the child prodigy Chiyo, the animal-loving Sakaki, the spacey out-of-towner Osaka, the straight-laced Yomi and her best friend Tomo, and the sports-loving Kagura throughout their high school lives. With its strong cast of characters and punchy dialogue, Azumanga Daioh has become one of the most widely-recognized books in the market, not to mention the first four-panel comic from Japan to gain wide popularity in the U.S.