Shopping Cart

ORDER TOTAL

0
Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis

By PETER GRUNWALD

Category:

Hardback

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer, β-Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases, and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy.

ISBN: 9789814877138

€270.20

  • Order by 6pm for same day dispatch*
  • In stock online
  • Delivery in 5-7 working days
  • Free Delivery

+ 1081 Reward Points

Dublog

Loading...

Delivery

Deliveries within Ireland:* 2–3 working days
Free delivery on orders over €20

*on in-stock items

Returns

Return your order within
14 days for full refund, or
within 28 days for store credit

Dubray Card

Earn 4 points with every €1 spent
Exclusive author content and book news
Pick up a card in your local Dubray